Synthesis and antihypertensive activity of 4'-{2-[4-[2-(Substituted- phenyl)-4-oxo-thiazolidin-3-yl]-phenyl} benzoimidazol-1-yl-methyl}- biphenyl-2-carboxylic acids
نویسندگان
چکیده
Structures of all the synthesized compounds have been corroborated on the basis of elemental IR, H NMR, C NMR and Mass spectro-analytical data. Many Schiff bases were prepared by condensation reaction of compounds containing biphenyl carboxylic acid with aromatic aryl aldehydes derivatives with Thiazoldine-4-one. The synthesized compounds 4'-{2-[4-[2(Substituted-phenyl)-4-oxo-thiazolidin-3-yl]-phenyl} benzoimidazol-1-ylmethyl}-biphenyl-2carboxylic acid react with mercaptoacetic acid and 4'-bromomethylbiphenyl-2-carboxylic acid and all synthesis compounds screened for Angiotension (A II) Receptor Antagonist antihypertensive activity with biphenyl carboxylic acid Schiff bases Thiazoldine-4-one shows good activity compared with losartan and Telmisartan.
منابع مشابه
Efficient Synthesis and Pharmacological Evaluation of 3-(4-{5-Amino-6- fluoro-1-[2'-(1H-tetrazole-5-yl)-biphenyl-4-ylmethyl]-1H-benzoimidazol-2-yl}- phenyl) -2-(substituted) - thiazolidin-4-one as Potent Antihypertensive Agents
Several substituted-benzimidazole 3-(4-{5-Amino-6-fluoro-1-[2'-(1H-tetrazole-5-yl)-biphenyl-4ylmethyl]-1H-benzoimidazol-2-yl}-phenyl) -2-(substituted)thiazolidin-4-one were synthesized by condensation of various steps with various substituted aryl aldehydes reaction. Elemental analysis, IR, 1HNMR and mass spectral data confirmed the structure of the newly synthesized compounds. Synthesized and ...
متن کاملSynthesis and pharmacological activity of 2-(2-substituted-phenyl)-3-(4-{1-[2- (1H-tetrazol-5-yl)-biphenyl-4-ylmethyl])-1H-benzoimidazol-2-yl}-phenyl)- thiazolidin-4-ones
An easy and efficient method to obtain Schiff bases of [2-(2-substituted-phenyl)-3-(4-{1-[2-(1Htetrazol-5-yl)-biphenyl-4-ylmethyl])-1H benzoimidazol-2-yl}-phenyl)thiazolidin-4-one] using different aromatic aldehydes. Reaction mixture of Schiff base (0.01 mol) and mercaptoacetic acid (0.05 mol) dissolved in dioxane (50 ml), anhydrous zinc chloride (0.008 mol) was added and refluxed for 12 hrs. T...
متن کاملSYNTHESIS AND PHARMACOLOGICAL INVESTIGATION OF SOME BENZYLIDENE-(2-{5, 6-SUBSTITUTED-1-[2-(1H-TETRAZOL-5-yl)-BIPHENYL-4- YLMETHYL]-1H-BENZOIMIDAZOL-2-YL}-PHENYL-AMINE IN THE PRESENCES OF BF3·OET2 CATALYSTS AS ANTIHYPERTENSIVE AGENTS
A series of Benzylidene-(2-{5, 6-substituted-1-[2-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]1H-benzoimidazol-2-yl}-phenyl-amine have been synthesized by 4'-{2-[2-(Benzylideneamino)-phenyl] 5, 6-substitutedbenzimidazol-1-yl}-biphenyl-2-carbonitrile.Preliminary screening of the title compounds for antihypertensive activity was performed. Only one of the compound was found to possess antihypertensive...
متن کاملA rational approach for synthesis, characterization and antihypertensive activity evaluation of 1-(4-{5-amino-6-fluoro-1-[2'-(2H-tetrazole-5-yl)- biphenyl-4-ylmethyl]-1H-benzoimidazol-2-yl}-phenyl)-3-chloro-4- (substituted -phenyl)-azetidin-2-ones
A new series of 1-(4-{5-Amino-6-fluoro-1-[2'-(2H-tetrazole-5-yl)-biphenyl-4-ylmethyl]-1Hbenzoimidazol-2-yl}-phenyl)-3-chloro-4-(Substituted -phenyl)-azetidin-2-one derivatives MCS 06[1-15] has been synthesized and subjected to evaluate their antihypertensive activity. All the synthesized compounds of the series elicit remarkable activity in comparison to standard drug (Losartan). Structures of ...
متن کاملSynthesis and Antihypertensive Activity of Some N-{4-(6-Chloro-5-nitro-1- [2'--(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-1H-benzoimidazol-2yl-}-phenyl)- 3-(substituted-phenyl)-acryl amides
A new series of N-{4-(6-Chloro-5-nitro-1-[2'--(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-1Hbenzoimidazol-2yl-}-phenyl)-3-(substituted-phenyl)-acryl amide derivatives [1-8] has been synthesized and subjected to evaluate their antihypertensive activity. All the synthesized compounds of the series displayed, remarkable activity in comparison to standard drug(losratan ). Many Schiff bases were prepare...
متن کامل